Tough pregnancy may raise wheeze risk in child
Children born to women who experience certain complications during pregnancy an? delivery are at increased risk for developing specific patterns of wheezing, according to a new report.
“This study adds weight to the epidemiological data which suggest that early development has significant consequences in disease risk not only in childhood (our study), but also throughout life,” Dr. Franca Rusconi told Reuters Health.
Rusconi from the University of Florence, Italy and colleagues in the SIDRIA Collaborative Group evaluated the associations between maternal medical complications and procedures during pregnancy and at delivery and the risks of various wheezing disorders — transient early wheezing, persistent wheezing and late-onset wheezing — in 15,609 children between 6 and 7 years old.
The team found that 9.5 percent of the children had transient early wheezing, 5.4 percent had persistent wheezing, and 6.1 percent had late-onset wheezing. Preeclampsia or high blood pressure requiring therapy was associated with an increased risk of all three wheezing types, the investigators report, increasing the odds by 40 percent, 59 percent, and 47 percent, respectively. Maternal diabetes was associated with a 72 percent increased risk of persistent wheezing.
Prescription of antibiotics for urinary tract infections and antibiotics administered at delivery were associated with early-onset transient and persistent wheeze, the results indicate. Prescription of antibiotics for respiratory infections was strongly associated with both persistent and late-onset wheezing, the researchers note.
Amniocentesis or chorionic villus sampling, cesarean section, and weight gain during pregnancy were not significantly associated with childhood wheezing, the investigators report in the American Journal of Respiratory and Critical Care Medicine.
Although a maternal history of asthma and/or allergy was also associated with wheezing in childhood, this history did not modify the association between maternal complications or procedures in pregnancy and at birth and wheezing phenotypes, the report indicates.
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